According to Dr. Charles Warren, the Whore of Babylon will represent Rome. The Book of Revelation says that during the Apocalypse, the Whore of Babylon will be killed by the ten kings who are given temporary power by the Devil. The kings will come to hate the Whore, and will make her desolate and naked; eating her flesh and burning her with fire.
An ancient statue of the Whore of Babylon is among the artefacts excavated in what appears to be Tel Megiddo. The statue is located in the chamber of Yigael's Wall. It is buried again when the chamber collapses, then re-excavated by Thorn Industries seven years later and scheduled to be shipped to the Thorn Museum in Chicago.
- Some fans believe that in Damien - Omen II, Ann Thorn represents the Whore of Babylon.